Los Angeles Chargers at Buffalo Bills (-4.5)
The Chargers are making a cross country flight to Buffalo to play a 1pm EST game. Los Angeles will likely have jet lag and will not be 100% against the Bills. The Chargers are also without cornerback Casey Hayward and linebacker Melvin Ingram.
Cleveland Browns at Jacksonville Jaguars: UNDER/48.5
The Jaguars are starting Quarterback Mike Glennon and are also without Wide Receivers D.J. Chark and Chris Conley. Jacksonville will not be able to move the ball in this game and could be shutout by the Cleveland Browns. The Jaguars also allow 129.1 rushing yards per game so expect a big game from Nick Chubb and Kareem Hunt.
Tennessee Titans at Indianapolis Colts: OVER/51.5
These two teams combined for 51 points on a Thursday night game two weeks ago. With this game not being played on a short week, both teams will find success on offense. DeForest Buckner is out for the Colts which will set up a big game for Derrick Henry. The Colts will also be able to move the ball, which will help the over hurt.